Since 2002, a number of new psychoactive substances have been included in the list of control drugs (Royal Decree of January 22, 1998). For instance, PMMA was added in 2002; BZP was added in 2004; pCPP in 2006; mephedrone in 2010; several synthetic cannabinoids (e.g. JWH-compunds, CP 47,497, HU-210), as well as synthetic cathinones such as bk-PMMA. In 2013, other synthetic cannabinoids (AM-compounds), synthetic cathinones (MDPV) and other substances (5-IT) were also added in 2011; other synthetic cannabinoids (such as AM- compounds, JWH- compounds, A-796,260), phenethylamines (3-MA, 4-MA), synthetic cathinones (MDPV), piperazines (pFPP); ketamine and phencyclidine type substances (4-MeO-PCP), among others were added to the list in 2013. In November 2015, the Royal Decree of January 22, 1998 was amended to implement the decision of the CND (68th Session) which placed under international control 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, AM-2201, mephedrone, BZP, MDPV, JWH-018 and methylone (bk-MDMA ). It also placed a large number of NPS under international control.